鄧桂芳,，副主任醫(yī)師，碩士研究生導(dǎo)師,，博士后合作導(dǎo)師,，華中科技大學(xué)協(xié)和深圳醫(yī)院臨床營(yíng)養(yǎng)科副主任（主持工作）,，東部戰(zhàn)區(qū)總醫(yī)院解放軍普通外科研究所臨床醫(yī)學(xué)博士后，中山大學(xué)營(yíng)養(yǎng)與食品衛(wèi)生學(xué)博士,，中華醫(yī)學(xué)會(huì)腸外與腸內(nèi)營(yíng)養(yǎng)分會(huì)世界營(yíng)養(yǎng)日協(xié)作組副組長(zhǎng),，中國(guó)醫(yī)師協(xié)會(huì)外科醫(yī)師分會(huì)臨床營(yíng)養(yǎng)專(zhuān)家工作組專(zhuān)家委員，廣東省營(yíng)養(yǎng)學(xué)會(huì)理事,，廣東省醫(yī)院協(xié)會(huì)醫(yī)院營(yíng)養(yǎng)管理協(xié)會(huì)副主任委員,，廣東省營(yíng)養(yǎng)學(xué)會(huì)醫(yī)學(xué)營(yíng)養(yǎng)食品專(zhuān)家組成員,，廣東省醫(yī)學(xué)會(huì)腸外腸內(nèi)營(yíng)養(yǎng)分會(huì)青年委員,，深圳市醫(yī)師協(xié)會(huì)營(yíng)養(yǎng)醫(yī)師分會(huì)副會(huì)長(zhǎng)，深圳市醫(yī)師協(xié)會(huì)老年醫(yī)學(xué)醫(yī)師分會(huì)理事,，深圳市營(yíng)養(yǎng)學(xué)會(huì)常務(wù)理事,，家庭營(yíng)養(yǎng)操作流程副主編。主持國(guó)家自然科學(xué)基金,、廣東省自然科學(xué)基金,、市及區(qū)級(jí)科研項(xiàng)目共10項(xiàng)，作為主要完成人參與國(guó)家自然科學(xué)基金面上項(xiàng)目,、省市級(jí)研項(xiàng)目,、橫向課題共10項(xiàng)。發(fā)表論文SCI論文32篇,，其中第一或通訊作者論文共18篇,，美國(guó)Nova 科學(xué)出版社Book Chapter一章，其他論文7篇,。SCI 論文被他引 1817次,，單篇論文最高被引用 663次。ESI (Essential Science Indicators) 收錄高引用論文2篇.中華醫(yī)學(xué)會(huì)第十四屆全國(guó)腸外腸內(nèi)營(yíng)養(yǎng)學(xué)學(xué)術(shù)會(huì)議優(yōu)秀論文一等獎(jiǎng),。

一. 主持或參加科研項(xiàng)目及人才計(jì)劃項(xiàng)目情況：

1. 深圳市南山區(qū)衛(wèi)生健康系統(tǒng)科技重大項(xiàng)目杰出青年基金. 基于多組學(xué)-機(jī)器學(xué)習(xí)技術(shù)篩選妊娠糖尿病早期預(yù)測(cè)生物標(biāo)志物的臨床研究.NSZD2023024. 2023.6-2026.6.50萬(wàn).主持.

2. 國(guó)家自然科學(xué)基金,，82103821,原花青素通過(guò)腸道菌群-膽汁酸軸下調(diào)FXR信號(hào)通路改善妊娠糖尿病的機(jī)制研究,2022,01-2024.12.30萬(wàn).主持。

3. 深圳市科創(chuàng)委基礎(chǔ)研究面上項(xiàng)目. JCYJ20210324112400002. 基于腸道菌群--膽汁酸--FXR信號(hào)通路探討原花青素對(duì)妊娠糖尿病的影響和機(jī)制.2021.10-2024.9,20萬(wàn),，在研,，主持。

4. 廣東省自然科學(xué)基金,，2019A1515110456,，黃烷醇腸道菌群代謝產(chǎn)物調(diào)節(jié)NLRP3炎癥小體在預(yù)防妊娠糖尿病的作用及機(jī)制研究， 2020-01至2022-12,，10萬(wàn),，結(jié)題，主持

5. 深圳市科技創(chuàng)新委員會(huì)2020年基礎(chǔ)研究面上項(xiàng)目,，黃烷醇腸道菌群依賴(lài)代謝產(chǎn)物與妊娠糖尿病的關(guān)系及NLRP3炎癥小體介導(dǎo)的機(jī)制研究.JCYJ20190809102203602.2020-2022,，10萬(wàn),主持,。

6. 廣東省營(yíng)養(yǎng)膳食與健康重點(diǎn)實(shí)驗(yàn)室開(kāi)放基金，原花青素經(jīng)調(diào)節(jié)腸道菌群-膽汁酸代謝對(duì)妊娠糖尿病的作用研究,，2022.05-2024.05,，2萬(wàn)，主持,。

7. 深圳市南山區(qū)科技計(jì)劃重點(diǎn)項(xiàng)目,，201907,腸道菌群構(gòu)成及短鏈脂肪酸與妊娠期糖尿病的關(guān)系研究，2020-2022,3萬(wàn),，主持,。

8. 廣東省醫(yī)學(xué)科研基金，基于大數(shù)據(jù)探討妊娠糖尿病新舊診斷標(biāo)準(zhǔn)對(duì)妊娠結(jié)局的影響,，NO. A2017159,，2017.7-2019.6. 1萬(wàn)，主持,。

9. 深圳市衛(wèi)生計(jì)生委科研項(xiàng)目,，健康膳食模式對(duì)深圳孕婦妊娠尿病影響，No. 201402136,，2014.8-2017.8,，非資助，主持,。

10. 南山區(qū)科技計(jì)劃項(xiàng)目,，于大數(shù)據(jù)探討妊娠糖尿病新診斷標(biāo)準(zhǔn)應(yīng)用對(duì)深圳女性妊娠結(jié)局的影響，No. 2016025,，2016.11-2018.11,，2.5萬(wàn)，主持,。

11. 院內(nèi)課題,，術(shù)前營(yíng)養(yǎng)風(fēng)險(xiǎn)評(píng)估及術(shù)前營(yíng)養(yǎng)支持對(duì)肝膽外科擇期手術(shù)患者術(shù)后臨床結(jié)局影響的前瞻性研究,2018.8-2020.8，5萬(wàn),，主持,。

12. 合生元母嬰營(yíng)養(yǎng)與護(hù)理研究基金項(xiàng)目，膳食及體內(nèi)脂肪酸對(duì)妊娠糖尿病孕婦糖脂代謝變化及子代生長(zhǎng)發(fā)育的影響及機(jī)制研究,，課題主要實(shí)施者,。BINCMYF19005，2019.7-2020.7,，20萬(wàn),，第二負(fù)責(zé)人。

二,、代表性科研成果

1. Yao Liu, Hengying Chen b, Yingyu Zhou, Xiaoping Lin, Lanyao Yang, Bowen Zhan,Yuanhuan Wei, Ruifang Sun, Hongguang Yang, Zheqing Zhang, Guifang Deng#.The association of serum toxic metals and essential elements during earlypregnancy with body mass index trajectory of infants during the first years:A prospective study. Ecotoxicology and Environmental Safety.2024.269.115766. (通訊作者,，IF 6.8)

2. Guifang Deng1?, Hengying Chen2?, Yao Liu, Yingyu Zhou,Xiaoping Lin, Yuanhuan Wei, Ruifang Sun, Zheqing Zhang*,Zhenhe Huang*.Combined exposure to multiple essential elements and cadmium at early pregnancy on gestational diabetes mellitus: a prospective cohort study. Frontiers in Nutrition .2023 6:10:1278617. (第一作者,，IF 5.0)

3. Yao Liu, Yuanhuan Wei, Lanlan Wu, Xiaoping Lin, Ruifang Sun, Hengying Chen, Siwen Shen, Guifang Deng#. Fructose Induces Insulin Resistance of Gestational Diabetes Mellitus in Mice via the NLRP3 Inflammasome Pathway Frontiers in Nutrition 2022 12;9:839174. doi: 10.3389/fnut.2022.839174. eCollection 2022. (通訊作者，IF 5.0)

4. Yao Liu, Ruifang Sun, XiaoPing Lin, Lanlan Wu, Hengying Chen, Siwen Shen,Yan Li, Yuanhuan Wei, Guifang Deng#. Procyanidins and its metabolites by gut microbiome improves insulin resistance in gestational diabetes mellitus mice model via regulating NF-κB and NLRP3 inflammasome pathway. Biomedicine & Pharmacotherapy. 2022,151: 113078. (通訊作者,，IF 7.419)

5. Wu L, Sun R, Liu Y, Liu Z, Chen H, Shen S, Wei Y, Deng G#. High hemoglobin level is a risk factor for maternal and fetal outcomes of pregnancy in Chinese women: A retrospective cohort study. BMC Pregnancy Childbirth. (2022) 22:290（通訊作者,，IF 3.105）

6. Lanlan Wu, Yao Liu, Zengyou Liu, Hengying Chen, Siwen Shen, Yuanhuan Wei, Ruifang Sun and Guifang Deng#. Serum urea acid and urea nitrogen levels

are risk factors for maternal and fetal outcomes of pregnancy: a retrospective cohort study. Reproductive Health. (2022) 19:192. （通訊作者，IF 3.355）

7. Lanyao Yang, Lanlan Wu, Yao Liu, Hengying Chen, Yuanhuan Wei, Ruifang Sun, Siwen Shen3,Bowen Zhan, Jianjun Yang, Guifang Deng#. Association Between Serum Ferritin Concentration and Risk of Adverse Maternal and Fetal Pregnancy Outcomes: A Retrospective Cohort Study. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2022:15 2867–2876. （通訊作者,，IF 3.249）

8. Guifang Deng, Qiucheng Lei, Xuejin Gao, Yupeng Zhang, Huazhen Zheng, Jingcheng Bi 5, Xinying Wang. Glucagon-Like Peptide-2 Modulates Enteric Paneth Cells Immune Response and Alleviates Gut Inflammation During Intravenous Fluid Infusion in Mice With a Central Catheter. Front Nutr 2021 Sep 3;8:688715. doi: 10.3389/fnut.2021.688715. eCollection 2021. (IF 5.0)

9. Yao Liu; Guifang Deng#; Xu Wang; Jing Luo; Xiaoyun Qian;Wenhua Ling . Cyanidin-3-O-β-glucoside Polarizes LPS-induced M1 into M2 Macrophage in J774 Cells via PPARγ-mediated NF-κB and STAT6 Signaling Pathway. J of Functional Foods.2021. 77.104314 （通訊作者,，IF 5.223）

10. Chen H^?, Deng G?, Zhou Q, Chu X, Su M, Wei Y, Li L, Zhang Z. Effects of eicosapentaenoic acid and docosahexaenoic acid versus α-linolenic acid supplementation on cardiometabolic risk factors: a meta-analysis of randomized controlled trials. Food Funct. 2020;11(3):1919-1932.(并列第一作者，IF 6.317)

11. Yan Li,* Tingwei Yu,* Zengyou Liu, Hengying Chen, et al. Guifang Deng#, Zheqing Zhang #. Association of Serum Uric Acid, Urea Nitrogen, and Urine Specific Gravity Levels at 16–18 Weeks of Gestation with the Risk of Gestational Diabetes Mellitus. Diabetes Metabolic Syndrome and Obesity- Targets and Therapy 2020:13:4689-4697（IF3.249,，通訊作者）

12. YaoLiu,RuifangSun,YanLi,HengyingChen,LanlanWu,SiwenShen,YuanhuanWei,NuoyaWang,ZheqingZhang,ZengyouLiu,GuifangDeng#.Changes in serum total bile acid concentrations are associated with the risk of developing adverse maternal and perinatal outcomes in pregnant Chinese women. Clinica Chimica Acta.2021.520: 160-167.（IF6.314,，通訊作者）

13. Hengying Chen,Zheqing Zhang,Yingyu Zhou,Yao Liu,Xiaoping Lin,Yuanhuan Wei,Ruifang Sun,Liping Li,Guifang Deng.Maternal leucocyte trajectory across pregnancy associated with offspring's growth. Pediatric Research.2022 Sep;92(3):862-870.（IF 3.933，并列通訊作者）

14. 孫瑞方,，吳蘭蘭,，劉 瑤,，韋遠(yuǎn)歡,，沈思文，王諾亞,，簡(jiǎn)西廷,，鄧桂芳.加速康復(fù)外科圍手術(shù)期營(yíng)養(yǎng)管理對(duì)兒童耳鼻喉外科病人臨床結(jié)局的影響. 腸外與腸內(nèi)營(yíng)養(yǎng).2022.29(6).342-346.

15. Li Zhang, Siwen Wang, Xuejin Gao , Tingting Gao , Lingli Huang , Bo Lian , Yingchao Gu , Jianjiao Chen, Dong Guo , Zhenyi Jia, Yong Wang , Fangyou Gong, Junde Zhou, Zhigang Xue, Zhida Chen, Jielian Xu, Leilei Wang, Jun Qian , Guifang Deng, Hao Hu, Yao Nie, Gang Li , Mengbin Li , Hua Yang , Wei Zhao , Yanbing Zhou, Huanlong Qin , Xiaoting Wu, Kunhua Wang, Qiang Chi , Jianchun Yu, Yun Tang, Pianhong Zhang, Gang Jin, Bin Ouyang, Guoli Li , Dong Hang and Xinying Wang. Frontiers in Nutrition. 2022.9:850063. (IF 6.591)

16. Chen Gengdong, Li Yan, Zeng Fangfang, Deng, Guifang, Liang Jingjing,Wang Jue; Su Yixiang, Chen Yuming, Mao Limei, Liu Zhengping, Bao Wei, Zhang, Zheqing. Biomarkers of fatty acids and risk of type 2 diabetes: a systematic review and meta-analysis of prospective cohort studies. Critical reviews in food science and nutrition. 2020. 10.1080/10408398.2020.1784839.（IF 11.208）

17. Gengdong Chen, Yan Li, Guifang Deng, Shiksha Shrestha, Fengyan Chen, Yuanhuan Wei, Zhaochang Huang, Jialiang Pan, Zheqing Zhang. Associations of Plasma Copper, Magnesium, and Calcium Levels With Blood Pressure in Children: A Cross-sectional Study. Biological Trace Element Research.2020. doi: 10.1007/s12011-020-02201-z.（IF 4.081）

18. Deng Gui-Fang, Nie Lei, Ai Wen, Wei Yuan-Huan, Sun Rui-Fang, Deng Xiu-Juan, Li Hua-Bin. Effects of Simulated Gastrointestinal Digestion on Antioxidant Activities of Individual and Mixed Fruits. North American Journal of Medicine and Science.2019.12(1):14-20.

19. 李艷,韋遠(yuǎn)歡,陳鳳燕,陳耿東,王晴柔,張喆慶#,鄧桂芳#.廣州市 6-9 歲兒童脂肪分布與妊娠期糖尿病的關(guān)聯(lián)研究.中國(guó)學(xué)校衛(wèi)生.2020

20. 鄧桂芳 ，李翠玉,，韋遠(yuǎn)歡 ,，王新穎. 術(shù)前口服營(yíng)養(yǎng)補(bǔ)充對(duì)消化道惡性腫瘤病人營(yíng)養(yǎng)狀況及臨床結(jié)局的影響. 腸外與腸內(nèi)營(yíng)養(yǎng).2019.26(4).208-211.

21. 鄧桂芳，韋遠(yuǎn)歡,，黃麗葵,，葉燕嫦. 妊娠期糖尿病系統(tǒng)化家庭管理對(duì)母嬰臨床結(jié)局的影響.海南醫(yī)學(xué). 2019.30(12).1-4.

22. 聶雷，周穎,，鄧桂芳*,，池蓮祥.深圳地區(qū)城市居民腰圍與血清胰島素水平關(guān)系的臨床研究. 廣西醫(yī)科大學(xué)學(xué)報(bào).2018.35（10）:1414-1417.

23. Mo, Ronghui, Liu Hongxu, Lai, Ritian, Deng, Guifang, Zhang Zheqing, Pei Zezhen, Li Huabin, Xia Enqin. Ultrasound-Assisted Upper Liquid Micro- extraction Coupled to Molecular Fluorescence for Detection of Bisphenol A in Commercial Beverages. Food Analytical Methods.2017.10: 1575-1581.（IF 3.498）

24. 聶雷，鄧桂芳,，鐘麗娣,，池蓮祥*.血清25羥基維生素D水平與糖代謝異常的關(guān)系探討.海南醫(yī)學(xué).2017.1023-1026.

25. 鄧桂芳，韓金玲,，鄧小榮,，謝有志，孫瑞方. 長(zhǎng)期單瓶補(bǔ)充腸外營(yíng)養(yǎng)致Wernicke腦病一例. 海南醫(yī)學(xué). 2017.28.770-773.

26. Deng GF,，Xu DP,，Li S，Li HB*. Optimization of Ultrasound-Assisted Extraction of Natural Antioxidants from Sugar Apple (Annona squamosa L.) Peel Using Response Surface Methodology,，Molecules,，2015,，20（11）：20448-20459. (IF 4.927)

27. Deng GF, Xu XR, Zhang Y, Li D, Gan RY, Li HB*. Phenolic compounds and bioactivities of pigmented rice. Critical Reviews in Food Science and Nutrition, 2013, 53: 296-306. (IF 11.208)

28. Deng GF, Lin X, Xu XR, Gao LL, Xie JF, Li HB*. Antioxidant capacities and total phenolic contents of 56 vegetables. Journal of Functional Foods, 2013, 5: 260-266. (IF 5.223)

29. Deng GF, Xu XR, Guo YJ, Ling WH, Li HB*. Determination of antioxidant property and their  lipophilic and hydrophilic phenolic contents in cereal grains. Journal of Functional Foods. 2012. 4: 906 – 914. (IF 5.223)

30. Deng GF, Shen C, Xu XT, Ling WH, Li HB*. Potential of Fruit Wastes as Natural Resources of Bioactive Compounds. International Journal of Molecular Sciences, 2012, 13: 8308-8323.  (IF 6.208)

31. Deng GF, Li K, Ma J, Liu F, Dai JJ, Li HB*. Aluminium content of some processed foods, raw materials and food additives in China by inductively coupled plasma–mass spectrometry. Food Additives and Contaminants: Part B, 2011,4: 248–253. (IF 3.964)

32. Guo YJ, Deng GF #, Xu XR, Wu S, Li S, Xia EQ, Li F, Chen F, Ling WH, Li HB*. Antioxidant capacities, phenolic compounds and polysaccharide contents of 49 edible macro-fungi. Food & Function, 2012. 3: 1195-1205. (IF 6.317)

33. Song Y, Deng GF #, Xu XR, Chen YH, Chen F, Li HB. Nitrate and nitrite content in bottled beverages by ion-pair high-performance liquid chromatography. Food Additives and Contaminants: Part B, 2013, 6:42-46. (IF 3.964)

34. Deng GF, Xu XR, Li S, Li F, Wu S, Li HB*. Natural Antioxidant In Food. In: Phytochemicals: Occurrence in Nature, Health Effects and Antioxidant Properties. Kuang Haixue (ed.), Nova Science Publishers Inc., New York, NY, USA. 2013, pp. 147-174.

35. Li Fang, Li Sha, Li Hua-Bin, Deng Gui-Fang, Ling Wen-Hua, Xu Xiang-Rong. Antiproliferative activities of tea and herbal infusions. Food& Function, 2013, 4, 530-538. (IF 6.317)

36. Xia En-Qin, Deng Gui-Fang, Guo Ya-Jun, Li Hua-Bin. Biological activities of polyphenols from grapes. International Journal of Molecular Sciences, 2010, 11: 622-646. (IF 6.208)

37. Fang Li, Sha Li, Hua-Bin Li, Gui-Fang Deng, Wen-Hua Ling, Shan Wu, Xiang-Rong Xu, Feng Chen. Antiproliferative activity of peels, pulps and seeds of 61 fruits. Journal of Functional Foods, 5(3), 2013, 1298–1309. (IF 5.223)

38. Xia En-Qin, Yu Ying-Ying, Xu Xiang-Rong, Deng Gui-Fang, Guo Ya-Jun, Li Hua-Bin. Ultrasound-assisted extraction of oleanolic acid and ursolic acid from Ligustrum lucidum Ait. Ultrasonics Sonochemistry. 2012.19: 772–776. (IF 9.336)

39. Chen Yong-Hong, Xia En-Qin, Xu Xiang-Rong, Ling Wen-Hua, Li Sha, Wu Shan, Deng Gui-Fang,  Zou Zhi-Fei, Zhou Jing, Li Hua-Bin. Evaluation of Acrylamide in Food from China by a LC/MS/MS Method. International Journal of Environmental Research and Public Health, 2012. 9: 4150-4158. (IF 4.614)

40. Chen Yong-Hong, Xia En-Qin, Xu Xiang-Rong, Li Sha, Ling Wen-Hua, Wu Shan, Deng Gui-Fang, Zou Zhi-Fei, Zhou Jing, Li Hua-Bin. Evaluation of Benzo[a]pyrene in Food from China by High-Performance Liquid Chromatography-Fluorescence Detection. International Journal of Environmental Research and Public Health, 2012, 9: 4159-4169. (IF 4.614)

41. Li, Sha; Li, Shu-Ke; Li, Hua-Bin; Xu, Xiang-Rong; Deng, Gui-Fang; Xu, Dong-Ping Processing and Impact on Antioxidants in Beverages. Antioxidant Capacities of Herbal Infusions. Preedy, V.2014,41-50.