強媛媛，女,，1985年7月出生,，研究生學歷，理學博士,，副教授,，碩士生導師。2018年7月獲中山大學分子醫(yī)學博士學位,，2018年9月至今為寧夏顱腦疾病重點實驗室——國家重點實驗室培育基地專職科研人員,，寧夏醫(yī)科大學生物化學與分子生物學系教師，中國腫瘤與微環(huán)境學會會員,。主要從事腫瘤復發(fā)轉(zhuǎn)移分子機制研究,，癲癇與腸道微環(huán)境及抗癲癇藥物的機制研究等方面的科研工作，主持參與國家級,、省部級,、校級項目5項，在國內(nèi)外期刊發(fā)表論文20余篇,，指導一名本科畢業(yè)生獲優(yōu)秀畢業(yè)生稱號,，指導本科生參加國家級大學生實驗設(shè)計大賽獲優(yōu)秀獎及“厚生杯”獲校級優(yōu)秀獎，指導一名研究生獲國家獎學金,。

研究方向簡介：

研究方向1：癲癇與腸道微環(huán)境的相關(guān)性

研究方向2：抗癲癇藥物的機制研究

在研項目：

1. ADAP2在腎透明細胞癌中的功能及機制研究

2. 不良預后因素ADAP2通過EMT促進腎透明細胞癌惡性行為的機制研究

個人代表作：

1. Qiang YY, Li CZ#, Sun R, Zheng LS, Peng LX, Yang JP, Meng DF, Lang YH, Mei Y, Xie P, Xu L, Cao Y, Wei WW, Cao L, Hu H, Yang Q, Luo DH, Liang YY, Huang BJ, Qian CN*. Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling, Journal of experiment and clinical cancer research, 2018 Feb 20;37(1):34.

2. Yuanyuan Qiang, Jianguo Niu, Yun Wu, Zhao Di, et al. . Discovery of a novel cysteine framework XXIV conotoxin from Conus striatus, S24a, with potential analgesic activity International Journal of Peptide Research and Therapeutics, (published online 7th, september, 2020) 27, 615–625 (2021).

3. Yuanyuan Qiang, Yun Wu, Di Zhao, Boyao Zha, Feng Wang, et.al. Discovery and Characterization of the Novel Conotoxin Lv1d from Conus lividus that Presents Analgesic Activity. Toxicon. 2021 Apr 30;194:70-78.

4. Peng XS#, Yang JP#, Qiang YY#,Sun R, Cao Y, Zheng LS, et al. PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling. Molecular cancer research : MCR. 2020;18(6):903-12.

5. Wu Y#, Qiang Y#,Cao K, Zhang W, Zhang G. Inhibitory effect of the antimicrobial peptide BLP-7 against Propionibacterium acnes and its anti-inflammatory effect on acne vulgaris. Toxicon : official journal of the International Society on Toxinology. 2020;184:109-15.

6. Wu Y#, Qiang Y#, Zhang G, Zhou M. Acute toxicity and micronucleus test of conotoxin lt14a in mice. Basic Clin Pharmacol Toxicol. 2021 Mar

7. Xu L, Huang TJ, Hu H, Wang MY, Shi SM, Yang Q, Lin F, Qiang YY, Mei Y, Lang YH, Li CZ, Peng LX, Zheng LS, Huang JL, Li XJ, Zhang SJ, Qian CN*, Huang BJ*. The developmental transcription factor IRF6 attenuates ABCG2 gene expression and distinctively reverses stemness phenotype in nasopharyngeal carcinoma, Cancer Lett, 2018 Sep 1;431:230-243

8. Xie P, Yang JP, Cao Y, Peng LX, Zheng LS, Sun R, Meng DF, Wang MY,；Mei Y；Qiang YY, Cao L, Xiang YQ, Luo DH, Yun JP, Huang BJ, Jia LJ, Qian CN*,；Promoting tumorigenesis in nasopharyngeal carcinoma, NEDD8 serves as a potential theranostic target,，Cell Death Dis，2017 Jun 1;8(6):e2834.

9. Meng DF, Xie P, Peng LX, Sun R, Luo DH, Chen QY, Lv X, Wang L, Chen MY, Mai HQ, Guo L, Guo X, Zheng LS, Cao L, Yang JP, Wang MY, Mei Y, Qiang YY, Zhang ZM, Yun JP, Huang BJ, Qian CN*. CDC42-interacting protein 4 promotes metastasis of nasopharyngeal carcinoma by mediating invadopodia formation and activating EGFR signaling, J Exp Clin Cancer Res, 2017 Jan 28;36(1):21.

10. Yang JP, Liao YD, Mai DM, Xie P, Qiang YY, Zheng LS, Wang MY, Mei Y, Meng DF, Xu L, Cao L, Yang Q, Yang XX, Wang WB, Peng LX, Huang BJ, Qian CN*. Tumor vasculogenic mimicry predicts poor prognosis in cancer patients: a meta-analysis, Angiogenesis, 2016 Apr;19(2):191-200.

11. Mei Y, Yang JP, Lang YH, Peng LX, Yang MM, Liu Q, Meng DF, Zheng LS, Qiang YY, Xu L, et al. Global expression profiling and pathway analysis of mouse mammary tumor reveals strain and stage specific dysregulated pathways in breast cancer progression. Cell Cycle. 2018;17(8):963-973

12. Hu H, Xu L, Chen Y, Luo SJ, Wu YZ, Xu SH, Liu MT, Lin F, Mei Y, Yang Q, Qiang YY, Lin YW, Deng YJ, Lin T, Sha YQ, Huang BJ, Zhang SJ. The Upregulation of Trophinin-Associated Protein (TROAP) Predicts a Poor Prognosis is Hepatocellular Carcinoma. J Cancer. 2019;10(4):957-967

13. Meng DF, Sun R, Peng LX, Huang YS, Yang Q, Luo DH, Hu WH, Xie FY, Luo W, Zhao C, Guo L, Mai HQ, Chen MY, Xie P, Zheng LS, Yang JP, Mei Y, Qiang YY, Xu L, Li CZ, Huang BJ, Qian CN, Sun R. A comparison of weekly versus 3-weekly cisplatin during concurrent chemoradiotherapy for locoregionally advanced nasopharyngeal carcinoma using intensity modulated radiation therapy: a matched study. J Cancer. 2018 Jan 1;9(1):92-99.

14. WuY; Wang Lei; Zhou Maojun; You Yuwen; Zhu Xiaoyan; Qiang Yuanyuan; Qin Mengying; Luo Shaonan; Ren Zhenghua;*Xu Anlong,，Molecular Evolution and Diversity of Conus Peptide Toxins, as Revealed by Gene Structure and Intron Sequence Analyses.PLos One, 8(12), 2013/12/13.

15. Wang L, Tang W, Wang X, Chen Y, Wu Y, Qiang Y, Feng Y, Ren Z, Chen S,，Xu A. PPIase is associated with the diversity of conotoxins from cone snail venom glands .Biochimie,2015/05

16. 王磊 ; 曾夏蕓; 強媛媛; 任政華.芋螺毒素lt1c的重組表達及鎮(zhèn)痛功能中.山大學學報(自然科學版), 2018, (02): 137-142

17. 王磊 ; 吳赟; 任政華; 強媛媛. T-超家族芋螺毒素S10a的制備及功能研究.中國海洋藥物, 2017, (03): 89-93

專利：

1. 中國南海疣鎬芋螺神經(jīng)毒素及其編碼序列和用途 201010620115.22（已授權(quán)）

2. 中國南海線紋芋螺毒素s21a的制備及應用201010620135.X（已授權(quán)）

聯(lián)系方式：[email protected]